Denamarin For Dogs

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Denamarin For Dogs

Denamarin Supports Liver Function

Denamarin contains S-Adenosylmethionine (SAMe) and silybin as a liver function enhancing supplement for cats, small dogs, medium and large dogs. Denamarin works the improve the function of your dog's compromised liver. Very often, the exact cause of liver dysfunction can be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly.

SAMe (S-Adenosylmethionine), as in Denamarin for dogs, markedly increases liver glutathione levels[1,2], an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin protects liver cells from cell death[3,4] and may help cell repair and regeneration.[5]

Denamarin also administers silybin, the most active and bio-available part of milk thistle extract, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

The new chewable tablets of Denamarin allow dogs to receive SAMe and silybin in a tasty treat, eliminating the need for daily doses. Chewable tablets allow for quicker uptake of the SAMe and less variability between dogs when compared to enteric-coated tablets.

While supporting the liver in dogs and cats, Denamarin benefits brain health. Research in dog aging and associated decreases in levels of S-Adenosylmethionine (SAMe) in cerebrospinal fluid, which surrounds the brain. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector.

Denamarin has no known serious side-effects. Your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, watch for improvements in your pet's attitude, appetite, and activity level.


 1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.

 2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.

 3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.

 4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003; abstract #134.

 5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.

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